Research

Safeguarding the future through AMR research

We are AMR ready

Research matters

AMR in Microbiomes and Implications for One Health

Innovative solutions for tackling AMR

Microbiome-based solutions for AMR

Current Projects and opportunities

AMR in Veterinary and Food Microbiology


  • Characterisation of zoonotic bacterial diseases in food products (e.g. in meat e.g. beef, chicken, pork or dairy e.g. cheeses, milk, yoghurt etc and the antimicrobial resistance profiles of identified populations.
  • Assessing the role of colostrum microbiome properties in the acquisition of antimicrobial resistance (AMR) in dairy stock.
  • Innovative feed additive supplements for modulating the rumen microbiome and udder health of dairy calves.
  • Understanding the influence of antibiotic-free feed supplements in gut and milk microbiome modulation and AMR
  • Innovative technologies to treat bovine mastitis
  • Antimicrobial peptides as natural food preservatives.


AMR in Human and Clinical Microbiology


  • Evaluating the archaeal resistome and implications for one health
  • Discovery and development of novel antimicrobial compounds from niche microbiomes e.g. seaweed
  • Development of alternative antimicrobial treatments for multidrug-resistant infections e.g. MDR bacteria and fungi e.g candida auris
  • Natural populations and resistomes of the vaginal microbiomes and implications for health and disease
  • The skin microbiome as a diagnostic tool for hormonal flux 



Publications

  1. Mulkern, A.J., Oyama, LB., Cookson, A.R. et al. Microbiome-derived antimicrobial peptides offer therapeutic solutions for the treatment of Pseudomonas aeruginosainfections. npj Biofilms Microbiomes 8, 70 (2022). https://doi.org/10.1038/s41522-022-00332-w 
  2. Oyama, L.B., Olleik, H., Teixeira, A.C.N. et al. In silico identification of two peptides with antibacterial activity against multidrug-resistant Staphylococcus aureus. npj Biofilms Microbiomes 8, 58 (2022). https://doi.org/10.1038/s41522-022-00320-0  
  3. Lawther K, Santos FG, Oyama LB, Rubino F, Morrison S, Creevey CJ, McGrath JW and Huws SA (2022) Resistome Analysis of Global Livestock and Soil Microbiomes. Front. Microbiol. 13:897905. doi: 10.3389/fmicb.2022.897905
  4. de Oliveira IMF, Godoy-Santos F, Oyama LB, Moreira SM, Dias RG, Huws SA, Creevey CJ, Mantovani HC. (2022) Whole-Genome Sequencing and Comparative Genomic Analysis of Antimicrobial Producing Streptococcus lutetiensis from the rumen. Microorganisms. 10(3):551. doi: 10.3390/microorganisms10030551. 
  5. Huws SA, Edwards JE, Lin W, Rubino F, Alston M, Swarbreck D, Caim S, Rees Stevens P, Pachebat J, Won W-Y, Oyama LB, Creevey CJ, Kingston-Smith AH. (2021) Microbiomes attached to fresh perennial ryegrass- are temporally resilient and adapt to changing ecological niches. Microbiome. 9:143 https://doi.org/10.1186/s40168-021-01087-w 
  6. Won MY, Oyama LB, Creevey CJ, Huws SA (2020). Can rumen bacteria communicate to each other? Microbiome. 21;8(1):23. doi: 10.1186/s40168-020-00796-y. 
  7. Sabino YMV, Santana MF, Oyama LB, Santos FG, Moreira AJS, Huws SA, Mantovani HC (2019). Characterization of antibiotic resistance genes in the species of the rumen microbiota. Nature Communications 10(1): 5252. doi: 10.1038/s41467-019-13118-0. 
  8. Huws, SA., Creevey, C., Oyama, LB., Mizrahi, I., Denman, SE et al (2018). Addressing global ruminant agricultural challenges through understanding the rumen microbiome: Past, present and future. Frontiers in Microbiolology. doi: 10.3389/fmicb.2018.02161. 
  9. Oyama LB, Girdwood SE, Cookson A, Fernandez-Fuentes N, Privé F, Wilkinson T, Lundy F, Mansour S, Hancock, RE, Golyshin P, Golyshina O, Mikut R, Hilpert K, Edwards JE, Creevey C, Huws SA. (2017) The rumen microbiome: An untapped goldmine for novel antimicrobial discovery.  Nature Publishing Journal Biofilms and Microbiomes 3:33. Doi:10.1038/s41522-017-0042-1. 
  10. Oyama LB, Crochet J-A, Edwards JE, et al (2017) Buwchitin: A ruminal peptide with antimicrobial potential against Enterococcus faecalis. Frontiers in Chemistry. 5:51. doi: 10.3389/fchem.2017.00051 
  11. Wilkinson T Cowan AA, Vallin HE, Onime L, Oyama LB, Cameron SJ, Gonot C, Moorby J, Waddams K, Theobald V, Leemans D, Bowra S, Nixey C, Huws SA. (2017) Characterisation of the turkey microbiome along the gastrointestinal tract of growing turkeys. Frontiers in Microbiology. 2;8:1089. doi: 10.3389/fmicb.2017.01089.  
  12. Randall CP, Oyama LB, Bostock JM, Chopra I, O'Neill AJ. The silver cation (Ag+): antistaphylococcal activity, mode of action and resistance studies. Journal of Antimicrobial Chemotherapy. 2013 Jan;68(1):131-8. doi: 10.1093/jac/dks372. Epub 2012 Sep 25. PMID: 23011288. 


Share by: